Increased Sensitivity of Platelets from Unstable Angina Patients to Adenosine Diphosphate-Induced Aggregation.
نویسندگان
چکیده
منابع مشابه
Fine structural alterations induced in platelets by adenosine diphosphate.
E CAPACITY of blood platelets to form closely knit aggregates underlies their crucial role in the physiology of hemostasis and pathology of thrombosis. Ollegaard in 1951’ reported that an extract of red blood cells could markedly increase the adhesiveness of platelets, and promote their aggregation.2 The substance causing increased platelet stickiness was later discovered to be a nucleotide, ad...
متن کاملAdenosine diphosphate-induced platelet aggregation in the states of hypercoagulability.
One hundred and seven patients with congestive heart failure, myocardial infarction and arteriosclerotic heart disease were studied by adenosine diphosphate-induced platelet aggregation, fibrinogen levels and ethanol gelation test. Both increases and decreases in platelet aggregation were observed. A significantly high percentage of patients showed a decreased platelet aggregation which was esp...
متن کاملBinding of adenosine diphosphate by isolated membranes from human platelets.
Binding of adenosine diphosphate by isolated membranes from human platelets has been demonstrated. The process was reversible, temperature-dependent, supported by calcium or magnesium ions, and influenced by the integrity of membrane protein sulfhydryl groups. Prior exposure of the isolated membranes to trypsin, chymotrypsin, or pronase resulted in significant inhibition of [i4C]ADP uptake. Ext...
متن کاملNMR-based plasma metabolic profiling in patients with unstable angina
Objective(s): Unstable angina (UA) is a form of the acute coronary syndrome (ACS) that affects more than a third of the population before age 70. Due to the limitations of diagnostic tests, appropriate identification of UA is difficult. In this study, we proceeded to investigate metabolite profiling in UA patients compared with controls to determine potential candidate...
متن کاملSynergism between collagen-adenosine diphosphate and collagen-epinephrine in platelets' aggregation: different dose response relationships.
OBJECTIVES To evaluate the possible synergistic interaction of collagen-adenosine diphosphate and collagen-epinephrine in aggregation of human platelets. METHODS An experimental study was carried out at Armed Forces Instiute of Pathology, Rawalpindi, Pakistan, from June 2001 to December 2002. The platelet aggregation was determined by means of turbidometric method, which measures changes in o...
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ژورنال
عنوان ژورنال: Journal of Clinical Biochemistry and Nutrition
سال: 1994
ISSN: 1880-5086,0912-0009
DOI: 10.3164/jcbn.16.201